▸ > 3 months Immunocompetent Children; Adults < 55 years
▸ Adults > 55 years; Alcoholics; Debilitating Illness
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Infants < 1 month
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Preferred Regimen
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▸ Ampicillin 200 mg/kg/day IV, q4h
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PLUS
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▸ Cefotaxime 200 mg/kg/day IV, q6h
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> 3 months Immunocompetent Children; Adults < 55 years†
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Preferred Regimen
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▸ Vancomycin Child: 60 mg/kg/day IV, q6h; Adult: 2 g/day IV, q12h
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PLUS
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▸ Cefotaxime Child: 200 mg/kg/day IV, q6h; Adult: 12 g/day IV, q4h OR ▸ Ceftriaxone Child: 100 mg/kg/day IV, q12h; Adult: 4 g/day IV, q12h OR ▸ Cefepime Child: 150 mg/kg/day IV, q8h; Adult: 6 g/day IV, q8h
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† Might be added Metronidazole Child: 30 mg/kg/day, q6h; Adult: 1500-2000 mg/day, q6h
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Adults > 55 years; Alcoholics; Debilitating Illness
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Preferred Regimen
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▸ Ampicillin Child: 200 mg/kg/day IV, q4h; Adult: 12 g/day IV, q4h
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PLUS
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▸ Vancomycin Child: 60 mg/kg/day IV, q6h; Adult: 2 g/day IV, q12h
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PLUS
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▸ Cefotaxime Child: 200 mg/kg/day IV, q6h; Adult: 12 g/day IV, q4h OR ▸ Ceftriaxone Child: 100 mg/kg/day IV, q12h; Adult: 4 g/day IV, q12h OR ▸ Cefepime Child: 150 mg/kg/day IV, q8h; Adult: 6 g/day IV, q8h
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Specific Situations†
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Preferred Regimen
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▸ Ampicillin Child: 200 mg/kg/day IV, q4h; Adult: 12 g/day IV, q4h
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PLUS
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▸ Vancomycin Child: 60 mg/kg/day IV, q6h; Adult: 2 g/day IV, q12h
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PLUS
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▸ Ceftazidime Child: 150 mg/kg/day IV, q8h; Adult: 6 g/day IV, q8h OR ▸ Meropenem Child: 120 mg/kg/day IV, q8h; Adult: 3 g/day IV, q8h
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† Hospital Acquired Meningitis; Posttraumatic Meningitis; Postneurosurgery Meningitis; Neutropenia; Impaired Cell-mediated Immunity
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