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Peritonitis   ▸  Primary Spontaneous Bacterial Primary Spontaneous Bacterial Preferred Regimen ▸ Cefotaxime 2 gm IV q8h (q4h, if life-threatening infection) OR ▸Ticaricillin Clavulanate 3.1 gm IV q6h OR ▸Piperacillin Tazobactam 3.375 gm IV q6h (or 4-hour infusion of 3.375 gm q8h) OR ▸Ceftriaxone 2 gm IV q24h OR ▸Ertapenem 1 gm IV q24h If resistant E. coli or Klebsiella species ▸ Imipenem 500 mg IV q6h OR ▸Meropenem 1000 mg IV q8h OR ▸Doripenem 500 mg IV q8h (1 hr infusion) If checking sensitivities, then start ▸ Ciprofloxacin 400 mg IV q12h OR ▸Levofloxacin 750 mg IV once daily OR ▸Moxifloxacin 400 mg IV once daily In addition to antibiotic, to decrease frequency of renal impairment start ▸IV Albumin 1.5 gm/kg at diagnosis and 1 gm/kg on day 3 Preventive regimen for chronic ascites ▸TMP-SMX-DS 1 tab po 5 days/week OR ▸Ciprofloxacin 750 mg po once/week