Brinzolamide
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi
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Black Box Warning
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See full prescribing information for complete Boxed Warning.
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Overview
Brinzolamide is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
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Off-Label Use and Dosage (Adult)
Guideline-Supported Use
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- Developed by:
- Class of Recommendation:
- Strength of Evidence:
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There is limited information regarding Off-Label Guideline-Supported Use of Brinzolamide in adult patients.
Non–Guideline-Supported Use
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- Dosing Information
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Brinzolamide in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
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- Dosing Information
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There is limited information regarding FDA-Labeled Use of Brinzolamide in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
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- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
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There is limited information regarding Off-Label Guideline-Supported Use of Brinzolamide in pediatric patients.
Non–Guideline-Supported Use
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- Dosing Information
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Brinzolamide in pediatric patients.
Contraindications
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Warnings
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See full prescribing information for complete Boxed Warning.
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Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Brinzolamide in the drug label.
Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Brinzolamide in the drug label.
Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous
Drug Interactions
- Drug
- Description
Use in Specific Populations
Pregnancy
- Pregnancy Category B
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Brinzolamide in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Brinzolamide during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Brinzolamide with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Brinzolamide with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Brinzolamide with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Brinzolamide with respect to specific gender populations.
Race
There is no FDA guidance on the use of Brinzolamide with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Brinzolamide in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Brinzolamide in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Brinzolamide in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Brinzolamide in patients who are immunocompromised.
Administration and Monitoring
Administration
Oral
Intravenous
Monitoring
There is limited information regarding Monitoring of Brinzolamide in the drug label.
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Description
IV Compatibility
There is limited information regarding IV Compatibility of Brinzolamide in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
Description
Management
Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Brinzolamide in the drug label.
Pharmacology
Mechanism of Action
- Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II), found primarily in red blood cells (RBCs), but also in other tissues. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure (IOP).
- AZOPT® (brinzolamide ophthalmic suspension) 1% contains brinzolamide, an inhibitor of carbonic anhydrase II (CA-II). Following topical ocular administration, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Structure
- AZOPT® (brinzolamide ophthalmic suspension) 1% contains a carbonic anhydrase inhibitor formulated for multidose topical ophthalmic use. Brinzolamide is described chemically as: (R)-(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno [3,2-e]-1,2-thiazine-6-sulfonamide-1,1- dioxide. Its empirical formula is C12H21N3O5S3, and its structural formula is:
- Brinzolamide has a molecular weight of 383.5 and a melting point of about 131°C. It is a white powder, which is insoluble in water, very soluble in methanol and soluble in ethanol.
- AZOPT® (brinzolamide ophthalmic suspension) 1% is supplied as a sterile, aqueous suspension of brinzolamide which has been formulated to be readily suspended and slow settling, following shaking. It has a pH of approximately 7.5 and an osmolality of 300 mOsm/kg.
- Each mL of AZOPT® (brinzolamide ophthalmic suspension) 1% contains: Active ingredient: brinzolamide 10 mg. Preservative: Benzalkonium chloride 0.1 mg. Inactives: mannitol, carbomer 974P, tyloxapol, edetate disodium, sodium chloride, purified water, with hydrochloric acid and/or sodium hydroxide to adjust pH.
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Brinzolamide in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Brinzolamide in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Brinzolamide in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Brinzolamide in the drug label.
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Description
How Supplied
There is limited information regarding Brinzolamide How Supplied in the drug label.
Storage
There is limited information regarding Brinzolamide Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Patient Counseling Information of Brinzolamide in the drug label.
Precautions with Alcohol
Alcohol-Brinzolamide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.[1]
Brand Names
There is limited information regarding Brinzolamide Brand Names in the drug label.
Look-Alike Drug Names
- A® — B®[2]
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- ↑ "AZOPT (BRINZOLAMIDE) SUSPENSION [ALCON LABORATORIES, INC.]".
- ↑ "http://www.ismp.org". External link in
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