Oxprenolol

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Oxprenolol
Clinical data
Pregnancy
category
  • AU: C
Routes of
administration		oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability20-70%
MetabolismHepatic
Elimination half-life1-2hours
ExcretionRenal
Lactic (In lactiferous females)
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC15H23NO3
Molar mass265.348

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]

Oxprenolol is an potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.

References

  1. ↑ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9–14. PMID 2897304.

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