Clopamide

Clopamide

File:Clopamide.svg
Clinical data
ATC code	C03BA03 (WHO)
Identifiers
IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl- benzamide
CAS Number	636-54-4
PubChem CID	2804
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C14H20ClN3O3S
Molar mass	345.846 g/mol

Clopamide is a piperidine diuretic.

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Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.