Multi-drug-resistant tuberculosis classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Classification
Based on the drug susceptibility testing of cinical isolates confirmed to be Mycobacterium tuberculosis, The strains are classified as follows. [1]
| Classification | Description |
|---|---|
| Monoresistance | Strain resistant to any one of the first line anti tubercular drugs |
| Polydrug resistance | Strain resistant to more than one first line anti tubercular drugs. (Other than both rifampicin and isoniazid) |
| Multidrug resistance | Strain resistant to both rifampicin and isoniazid |
| Extensive drug resistance | In addition to the multi drug resistance, strain is resistant to any fluroquinolone and to atleast one of the three second line anti injectable drugs like amikacin, capreomycin and kanamycin. |
| Rifampicin resistance | Using genotypic or phenotypic method, strain has been detected to have resistance to rifampicin with or without resistance to other anti TB drugs. It can include monoresistance, multi drug resistance, poly drug resistance or extensive drug resistance. |
Clinical classification
Clinically drug resistant tuberculosis can be classified into acquired drug resistance and primary drug resistance according to pathophysiology.