WBR0141
| Author | [[PageAuthor::Rim Halaby, M.D. [1], Alison Leibowitz [2] (Reviewed by Alison Leibowitz)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Immunology |
| Sub Category | SubCategory::General Principles |
| Prompt | [[Prompt::Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the stromal compartment is called extravasation, and can be divided into four steps. Which of the following signaling mediators is involved in the migration of neutrophils across endothelial cells?]] |
| Answer A | AnswerA::E selectin and P selectin |
| Answer A Explanation | [[AnswerAExp::E selectin and P selectin are involved in the rolling phase of extravasation.]] |
| Answer B | AnswerB::ICAM 1 |
| Answer B Explanation | [[AnswerBExp::ICAM-1 is involved in the tight binding of neutrophils to the endothelium.]] |
| Answer C | AnswerC::PECAM 1 |
| Answer C Explanation | [[AnswerCExp::PECAM-1 is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells.]] |
| Answer D | AnswerD::C5a |
| Answer D Explanation | [[AnswerDExp::C5a is involved in the migration of leykocytes through the interstitum towards the site of inflammation.]] |
| Answer E | AnswerE::Interleukin 8 |
| Answer E Explanation | [[AnswerEExp::Interleukin 8 is involved in the migration of leukocytes through the interstitium towards the site of inflammation.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::PECAM-1 is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells.
The four steps of extravasation are:
Educational Objective: PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across endothelial cells. |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::Inflammation, WBRKeyword::Diapedesis, WBRKeyword::Leukocyte, WBRKeyword::Leukocyte adhesion, WBRKeyword::Endothelium, WBRKeyword::Endothelial cell |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |