Medroxyprogesterone acetate (oral)
Synonyms / Brand Names: Medroxyprogesteronum, Medroxyprogesteron acetate, Medroxyprogesteron, Medroxiprogesteronum, Medroxiprogesterona, Medrossiprogesterone, Medroprogesterone Acetate, MAP, Hydroxymethylprogesterone, CBP-1011, Aragest, Aragest 5, Asconale, Clinofem, Clinovir, Colirest, DMPA, Depo-Clinovir, Depo-Prodasone, Depo-Progestin, Depo-Promone, Depot-Medroxyprogesterone acetate, Farlutal, Farlutin, G-Farlutal, Gestapuran, Hematrol, Hysron, Indivina, Lunelle, Lutopolar, Lutoral, Med-Pro, Meprate, Metigestrona, MPA Gyn 5, Nadigest, Nidaxin, Novo-Medrone, Oragest, Perlutex, Perlutex Leo, Prodasone, Progestalfa, Progevera, Proverone, Ralovera, Repromap, Repromix, Sirprogen, Sodelut G, Veramix
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
Vasomotor Symptoms / Vulvar and Vaginal Atrophy
Patients should be treated with the lowest effective dose. Generally women should be started at
0.3 mg/1.5 mg PREMPRO daily. Subsequent dosage adjustment may be made based upon the
individual patient response. In patients where bleeding or spotting remains a problem, after appropriate
evaluation, consideration should be given to changing the dose level. This dose should be periodically
reassessed by the healthcare provider.
Postmenopausal Osteoporosis
Patients should be treated with the lowest effective dose. Generally women should be started at
0.3 mg/1.5 mg PREMPRO daily. Dosage may be adjusted depending on individual clinical and bone
mineral density responses. This dose should be periodically reassessed by the healthcare provider.
In patients where bleeding or spotting remains a problem, after appropriate evaluation, consideration
should be given to changing the dose level. This dose should be periodically reassessed by the
healthcare provider.
PREMPHASE therapy consists of two separate tablets; one maroon 0.625 mg Premarin tablet taken
daily on days 1 through 14 and one light-blue tablet, containing 0.625 mg conjugated estrogens and
5 mg of medroxyprogesterone acetate, taken on days 15 through 28.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Medroxyprogesterone acetate (oral)
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Publication Resources
Most Recent Articles on Medroxyprogesterone acetate (oral)
Review Articles on Medroxyprogesterone acetate (oral)
Articles on Medroxyprogesterone acetate (oral) in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Medroxyprogesterone acetate (oral)
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Trial Resources
Ongoing Trials with Medroxyprogesterone acetate (oral) at Clinical Trials.gov
Trial Results with Medroxyprogesterone acetate (oral)
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Medroxyprogesterone acetate (oral)
Cochrane Collaboration on Medroxyprogesterone acetate (oral)
Cost Effectiveness of Medroxyprogesterone acetate (oral)
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Media Resources
Powerpoint Slides on Medroxyprogesterone acetate (oral)
Images of Medroxyprogesterone acetate (oral)
Podcasts & MP3s on Medroxyprogesterone acetate (oral)
Videos on Medroxyprogesterone acetate (oral)
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Medroxyprogesterone acetate (oral)
Discussion Groups on Medroxyprogesterone acetate (oral)
Patient Handouts on Medroxyprogesterone acetate (oral)
Blogs on Medroxyprogesterone acetate (oral)
Medroxyprogesterone acetate (oral) in the News
Medroxyprogesterone acetate (oral) in the Marketplace
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International Resources
Medroxyprogesterone acetate (oral) en Español
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Adapted from the FDA Package Insert.