Opioid intoxication

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Differential Diagnosis

• Other substance intoxication

• Alcohol intoxication
• Sedative-hypnotic intoxication

• Other opioid-related disorders

• Opioid-induced depressive disorder

Diagnostic Criteria

DSM-V Diagnostic Criteria for Opioid Intoxication

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A.Recent use of an opioid. AND B.Clinically significant problematic behavioral or psychological changes (e.g., initial euphoria followed by apathy, dysphoria, psychomotor agitation or retardation, impaired judgment) that developed during, or shortly after, opioid use. AND C.Pupillary constriction (or pupillary dilation due to anoxia from severe overdose) and one (or more) of the following signs or symptoms developing during, or shortly after, opioid use: 1.Drowsiness or coma. 2.Slurred speech. 3.Impairment in attention or memory. AND D.The signs or symptoms are not attributable to another medical condition and are not better explained by another mental disorder, including intoxication with another substance. Specify if: With perceptual disturbances: This specifier may be noted in the rare instance in which hallucinations with intact reality testing or auditory, visual, or tactile illusions occur in the absence of a delirium.

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