Prednisolone (injection)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];
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Overview
Prednisolone (injection) is {{{aOrAn}}} {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. Common adverse reactions include {{{adverseReactions}}}.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Prednisolone (injection) FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Prednisolone in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisolone in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Prednisolone (injection) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Prednisolone in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisolone in pediatric patients.
Contraindications
There is limited information regarding Prednisolone (injection) Contraindications in the drug label.
Warnings
There is limited information regarding Prednisolone (injection) Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Prednisolone (injection) Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Prednisolone (injection) Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Prednisolone (injection) Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Prednisolone (injection) in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Prednisolone (injection) in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Prednisolone (injection) during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Prednisolone (injection) in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Prednisolone (injection) in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Prednisolone (injection) in geriatric settings.
Gender
There is no FDA guidance on the use of Prednisolone (injection) with respect to specific gender populations.
Race
There is no FDA guidance on the use of Prednisolone (injection) with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Prednisolone (injection) in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Prednisolone (injection) in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Prednisolone (injection) in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Prednisolone (injection) in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Prednisolone (injection) Administration in the drug label.
Monitoring
There is limited information regarding Prednisolone (injection) Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Prednisolone (injection) and IV administrations.
Overdosage
There is limited information regarding Prednisolone (injection) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Prednisolone (injection) Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Prednisolone (injection) Mechanism of Action in the drug label.
Structure
There is limited information regarding Prednisolone (injection) Structure in the drug label.
Pharmacodynamics
There is limited information regarding Prednisolone (injection) Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Prednisolone (injection) Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Prednisolone (injection) Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Prednisolone (injection) Clinical Studies in the drug label.
How Supplied
There is limited information regarding Prednisolone (injection) How Supplied in the drug label.
Storage
There is limited information regarding Prednisolone (injection) Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Prednisolone (injection) Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Prednisolone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Prednisolone (injection) Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Prednisolone (injection) Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
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| Pharmacokinetic data | |
| Elimination half-life | 2-3 hours |
| Identifiers | |
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| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C21H28O5 |
| Molar mass | 360.444 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Prednisolone is the active metabolite of prednisone.
Prednisolone has an extremely bitter taste that makes it difficult to administer to children.
Uses
It is a corticosteroid drug with predominantly glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, rheumatoid arthritis, Ulcerative Colitis and Crohn's disease, multiple sclerosis, cluster headaches and Systemic Lupus Erythematosus. It can also be used as an immunosuppressive drug for organ transplants and in cases of adrenal insufficiency (Addison's). Prednisolone acetate ophthalmic suspension is an adrenocortical steroid product prepared as a sterile ophthalmic suspension, used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. There is no generally-accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Corticosteriods are capable of producing a rise in intraocular pressure.
Possible Side-Effects
Possible side-effects include fluid retention of the face (moon face, Cushing's syndrome), acne, constipation, and mood swings. A lengthy course of prednisolone can cause bloody or black tarry stools; filling or rounding out of the face; muscle cramps or pain; muscle weakness; nausea; pain in back, hips, ribs, arms, shoulders, or legs; reddish-purple lines on arms, face, legs, trunk or groin; thin and shiny skin; unusual bruising; urinating at night; rapid weight gain; and wounds that will not heal. Swelling of the pancreas has also been reported. Other effects include decreased or blurred vision, increased thirst, confusion, and nervousness. It also is reported to cause insomnia when large strengths, or large doses are taken.
Systemically: Posterior subcapsular cataracts & papilledema
Topical: PSC & glaucoma
Contraindicated with herpes
Banned Status in Athletics
As a glucocorticosteroid, prednisolone is banned under WADA anti-doping rules.
Template:Corticosteroids Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents Template:Vasoprotectives Template:Corticosteroids for systemic use
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- Glucocorticoids