Nandrolone

Nandrolone

Clinical data
Pregnancy category	X (US) X (AUS)
Routes of administration	Intramuscular
ATC code	A14AB01 (WHO)
Legal status
Legal status	Schedule III (US) POM (UK)
Pharmacokinetic data
Bioavailability	2.24% (Oral) 100% (Intramuscular)
Metabolism	Hepatic
Elimination half-life	15 days
Excretion	Undocumented
Identifiers
IUPAC name (8R,9S,10R,13S,14S,17S)-17-hydroxy-13-methyl- 2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro- 1H-cyclopenta[a]phenanthren-3-one
CAS Number	434-22-0
PubChem CID	9904
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H26O2
Molar mass	274.40

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin).

Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women (though now not recommended) at a dose of 50 mg every three weeks. It is also used for some aplastic anaemias.

Metabolism

Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. The drug is also unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product known as Dihydronandrolone. As such, some of the negative effects associated with most such drugs are somewhat mitigated.

The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, in the United States nandrolone received FDA approval in 1983, and while sale in the U.S. is now restricted by the Controlled Substances Act, nandrolone remains available by prescription in most countries which have not adopted American-style "War on Drugs" anti-steroid campaigns. In addition to legal production, Nandrolone is also extensively used by bodybuilders and other athletes seeking an edge in professional competition.

Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also mitigated as a result of the drug being a progestin, but effects such as gynaecomastia and reduced libido still occur in larger doses. Other side-effects can include erectile dysfunction (coined as "Deca Dick") and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback.

Detection methods

Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolite of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping.

Urine analysis as a method of detecting nandrolone abuse has recently become somewhat controversial, following studies by the University of Aberdeen showing that the metabolite product can also show up in urine in quantities above the upper limit from a combination of high-protein diets utilising the legal nutritional supplement creatine and hard cardiovascular exercise. The reason for this unexpected result has not been determined. Another possible (though unlikely) reason for a false positive result is the consumption of beef from cattle treated with steroids including nandrolone (used in overturning the verdict against the bobsleigh racer, Lenny Paul). Heavy consumption of the essential amino acid lysine (as indicated in the treatment of cold sores) has also shown false positives in some and was cited by American Shotputter C.J. Hunter as the reason for his positive test. A final possible cause of incorrect urine test results is the presence of metabolites from other anabolic steroids.

QV Nandrolone Deca, a form of nandrolone used by athletes.

References

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