Triclosan

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Triclosan
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

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Overview

Triclosan is a antiseptic that is FDA approved for the {{{indicationType}}} of for hand washing to decrease bacteria on skin. Common adverse reactions include hypersensitivity.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • For hand washing to decrease bacteria on skin
  • Recommended for repeated use

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Triclosan in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Triclosan in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • For hand washing to decrease bacteria on skin
  • Recommended for repeated use

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Triclosan in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Triclosan in pediatric patients.

Contraindications

There is limited information regarding Triclosan Contraindications in the drug label.

Warnings

  • For external use only.
  • When using this product avoid contact with eyes. In case of eye contact, flush eyes with water.
  • Stop use and ask a doctor if irritation or redness develops, or if condition persists for more than 72 hours.
  • Keep out of reach of children.
  • If swallowed, get medical help or contact a Poison Control Center right away.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Triclosan in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Triclosan in the drug label.

Drug Interactions

There is limited information regarding Triclosan Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Triclosan in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Triclosan during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Triclosan with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Triclosan with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Triclosan with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Triclosan with respect to specific gender populations.

Race

There is no FDA guidance on the use of Triclosan with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Triclosan in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Triclosan in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Triclosan in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Triclosan in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Topical

Monitoring

There is limited information regarding Monitoring of Triclosan in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Triclosan in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Triclosan in the drug label.

Pharmacology

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Template:Chembox header2 | Triclosan
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
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KEGG
UNII
Properties
C12H7Cl3O2
Molar mass 289.54 g·mol−1
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

  • At high concentrations, triclosan acts as a biocide with multiple cytoplasmic and membrane targets.[1] However, at the lower concentrations seen in commercial products, triclosan appears bacteriostatic, and it targets bacteria primarily by inhibiting fatty acid synthesis.
  • Triclosan binds to bacterial enoyl-acyl carrier protein reductase (ENR) enzyme, which is encoded by the gene FabI. This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable, ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for building and reproducing cell membranes. Humans do not have an ENR enzyme and thus are not affected.

Structure

File:Triclosan01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Triclosan in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Triclosan in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Triclosan in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Triclosan in the drug label.

How Supplied

There is limited information regarding Triclosan How Supplied in the drug label.

Storage

There is limited information regarding Triclosan Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Triclosan |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Triclosan |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Triclosan in the drug label.

Precautions with Alcohol

  • Alcohol-Triclosan interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • ANTIBACTERIAL SPRAY®[2]

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Russell AD (2004). "Whither triclosan?". J Antimicrob Chemother. 53 (5): 693–5. doi:10.1093/jac/dkh171. PMID 15073159. Check |pmid= value (help).
  2. ↑ "ANTIBACTERIAL SPRAY - triclosan liquid".
  3. ↑ "http://www.ismp.org". External link in |title= (help)

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 |Label Name=Triclosan 01.jpg

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