Leukocytosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Leukocytosis or an elevated white blood cell count is a common laboratory with a wide range of causes.

Causes

Common Causes

• Infections
• Inflammation
• Leukemia
• Lymphoma
• Myelodysplastic syndrome
• Pneumonia
• UTI
• URI
• Colitis
• Cholecystitis
• Cellulitis
• Pancreatitis

Causes by Organ System

Cardiovascular	Myocardial infarction
Chemical/Poisoning	Thallium poisoning , Strychnine poisoning , Glufosinate poisoning , Chlorine Dioxide poisoning , Acute Pesticide poisoning , Acetylene Tetrabromide poisoning
Dental	No underlying causes
Dermatologic	Psoriasis , Pemphigus vulgaris , Generalized pustularpsoriasis , Eosinophilic pustular folliculitis , Dermatitis herpetiformis , Dermatitis
Drug Side Effect	Arsenic trioxide, Atropine, Aztreonam, Clomifene, Cefpodoxime, Cidofovir, Phenytoin , Lithium , Glucocorticoids ,Febuxostat, Filgrastim , Epinephrine , Echinacea , Aminophylline , Allopurinol, Abciximab, Meropenem, Pergolide, Plerixafor, Pramipexole, Tacrolimus, Thalidomide, Tretinoin
Ear Nose Throat	No underlying causes
Endocrine	Hyperthyroidism , Hypothyroidism , Hypoglycemia , Diabetes , Adrenal hemorrhage
Environmental	Heatstroke , Exercise , Cigarette smoking
Gastroenterologic	Ulcerative colitis , Pancreatitis , Pancreatic abscess , Jaundice , Ischemic colitis , Hepatitis B , Hepatitis A , Gallbladder empyema , Ascending cholangitis , Alcoholic Hepatitis
Genetic	Down syndrome
Hematologic	Splenectomy , Plasma cell leukemia , Non-Hodgkin lymphoma , Myeloproliferative diseases , Myeloma , Myelofibrosis , Mast cell leukemia , Lymphangitis, Leukocyte adhesion deficiency , Leukaemoid reaction , Leukaemia , Langerhans cell histiocytosis , Juvenile Myelomonocytic Leukemia (JMML) , Hyposplenism , Hodgkin lymphoma , Hereditary neutrophilia , Hepatosplenic T-cell lymphoma , Hairy cell leukaemia , Granulocyte colony stimulating factor , Generalized marrow stimulation , Familial myeloproliferative disease, Eosinophilic fasciitis , Chronic Myeloproliferative Disease , Chronic myeloid leukaemia , Chronic lymphocytic leukaemia , Chronic idiopathic neutrophilia , Chronic eosinophilic leukaemia, Burkitt lymphoma, Autoimmune lymphoproliferative syndrome type 2 , Autoimmune lymphoproliferative syndrome type 1 , Asplenia , Acute promyelocytic leukemia , Acute myeloid leukemia , Acute lymphoblastic leukemia , Acute basophilic leukaemia
Iatrogenic	Postpericardiotomy syndrome
Infectious Disease	Whooping cough , Toxoplasma , Syphilis , Staphylococcal , toxic shock syndrome , Spirometra mansoni infection , Sepsis , Secondary syphilis , Scarlet fever , Rubella , Prostatitis , Pneumonia , Peritonitis , organizing pneumonia , Mycobacterium tuberculosis , Meningococcal Infections , Infectious mononucleosis , Fungal infection , Epstein-Barr virus , Empyema Thoracis , Diverticulitis , Disseminated Intravascular Coagulation , Cytomegalovirus , Cryoglobulinemia , Chickenpox , Brucellosis , Bacterial infection , Acute/chronic infection
Musculoskeletal/Orthopedic	Polymyositis , septic arthritis , Osteomyelitis
Neurologic	Brain Abscess , Meningitis , encephalitis , SAH
Nutritional/Metabolic	Acute intermittent porphyria
Obstetric/Gynecologic	Pregnancy, PID
Oncologic	Nonhematologic malignancy , Cancer
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Bronchiolitis obliterans , Pneumonia , Empyema
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Wegener granulomatosis , Urate crystal arthropathy , Systemic lupus erythematosus , adult-onset Still disease , Serum sickness , Rheumatoid arthritis , Rheumatic fever , Polyarteritis nodosa , Hypersensitivity reaction type 3 , Connective tissue disease , Churg-Strauss syndrome
Sexual	STD , Gonorrhea
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Tissue damage , Sweet Syndrome , Stress , Spurious , Schnitzler syndrome , Polymer Fume Fever , Neuroleptic malignant syndrome , Lemierre's Syndrome , Idiopathic , Fanconi-Albertini-Zellweger syndrome , Familial Cold Autoinflammatory Syndrome (FCAS) , Familial cold autoinflammatory syndrome , Congenital anomalies and leukemia , Cholesterol Emboli Syndrome , Catecholamines , Burns ,Aseptic abscesses syndrome , Acute/chronic inflammation , Acute Chest Syndrome , Acute abdomen

Causes in Alphabetical Order

Abciximab Acetylene Tetrabromide poisoning Acute abdomen Acute basophilic leukaemia Acute Chest Syndrome Acute intermittent porphyria Acute lymphoblastic leukemia Acute myeloid leukemia Acute Pesticide poisoning Acute promyelocytic leukemia Acute/chronic infection Acute/chronic inflammation Adrenal hemorrhage Alcoholic Hepatitis Allopurinol hypersensitivity syndrome Aminophylline Ascending cholangitis Aseptic abscesses syndrome Asplenia Autoimmune lymphoproliferative syndrome type 1 Autoimmune lymphoproliferative syndrome type 2 Aztreonam Bacterial infection Bacterial toxic-shock syndrome Brain Abscess Bronchiolitis obliterans Brucellosis Burkitt lymphoma Burns Cancer Catecholamines Chickenpox Chlorine Dioxide poisoning Cholesterol Emboli Syndrome Chronic eosinophilic leukaemia Chronic idiopathic neutrophilia Chronic lymphocytic leukaemia Chronic myeloid leukaemia ChronicMyeloproliferative Disease Churg-Strauss syndrome Cidofovir Cigarette smoking Congenital anomalies and leukemia Connective tissue disease Cryoglobulinemia Cytomegalovirus Dermatitis herpetiformis Dermatitis Diabetes Disseminated Intravascular Coagulation Diverticulitis Down syndrome

Echinacea Empyema Thoracis Eosinophilic fasciitis Eosinophilic pustular folliculitis Epinephrine Epstein-Barr virus Exercise Familial]] Cold Autoinflammatory Syndrome (FCAS) Familial cold autoinflammatory syndrome Familial myeloproliferative disease]] Fanconi-Albertini-Zellweger syndrome Filgrastim Fungal infection Gallbladder empyema Generalized marrow stimulation Generalized pustular psoriasis Glucocorticoids Glufosinate poisoning Granulocyte colony stimulating factor Hairy cell leukaemia Heatstroke Hepatitis A Hepatitis B Hepatosplenic T-cell lymphoma Hereditary neutrophilia Hodgkin lymphoma Hypersensitivity reaction type 3 Hypoglycemia Hyposplenism Hypothyroidism Idiopathic Infectious mononucleosis Ischemic colitis Jaundice Juvenile Myelomonocytic Leukemia (JMML) Langerhans cell histiocytosis Lemierre's Syndrome Leukaemia Leukaemoid reaction Leukocyte adhesion deficiency Lithium Lymphangitis Mast cell leukemia Meningococcal Infections Mycobacterium tuberculosis Myelofibrosis Myeloma Myeloproliferative diseases Myocardial infarction

Neuroleptic malignant syndrome Non-Hodgkin lymphoma Nonhematologic malignancy organizing pneumonia overactive thyroid Pancreatic abscess Pancreatitis Pemphigus vulgaris Pergolide Peritonitis Phenytoin Plasma cell leukemia Plerixafor Pneumonia Polyarteritis nodosa Polycythaemia rubra vera Polymer Fume Fever Polymyositis Postpericardiotomy syndrome Pregnancy Prostatitis Psoriasis Rheumatic fever Rheumatoid arthritis Rubella Scarlet fever Schnitzler syndrome Secondary syphilis Sepsis Serum sickness Spirometra mansoni infection Splenectomy Spurious Staphylococcal toxic shock syndrome Still disease, adult-onset Stress Strychnine poisoning Sweet Syndrome Syphilis, congenital Systemic lupus erythematosus Thallium poisoning Tissue damage Toxoplasma Trauma Tretinoin Ulcerative colitis Urate crystal arthropathy Wegener granulomatosis Whooping cough

References