Sertaconazole

Sertaconazole

File:Sertaconazole.svg
Clinical data
[[Regulation of therapeutic goods |Template:Engvar data]]	US FDA: Sertaconazole
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Topical
ATC code	D01AC14 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Negligible
Protein binding	>99% to plasma
Identifiers
IUPAC name 1-[2-[(7-chlorobenzothiophen-3-yl) methoxy]- 2-(2,4-dichlorophenyl)- ethyl] imidazole
CAS Number	99592-32-2
PubChem CID	65863
DrugBank	APRD00305
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C20H15Cl3N2OS
Molar mass	437.77 g/mol

Sertaconazole nitrate (Ertaczo®) is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot.

Mechanism of action

The mechanism of action of sertaconazole is not fully understood. It is believed that, as all imidazole antifungals, sertaconazole inhibits the synthesis of ergosterol by the fungal cell. Ergosterol is a key component of the cell membrane of fungi, and lack of this component leads to leakage of the cell contents and ultimately to cell death.

Microbiology

Susceptible organisms

• Trichophyton rubrum
• Trichophyton mentagrophytes
• Epidermophyton floccosum

Side effects

Side effects were rarely reported with sertaconazole therapy, but may include contact dermatitis, burning on application site and skin dryness.

External links

• Ertaczo prescribing information