Alclometasone
File:Alclometasone.png | |
Clinical data | |
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Routes of administration | topical |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C28H37ClO7 |
Molar mass | 521.042 g/mol |
Description
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.
Pharmacology
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins;
inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid,
reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).
Indications
Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Contraindications
Side effects
Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:
How supplied
Alclometasone as Aclovate® is supplied in:
External links
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- Glucocorticoids