Pyridoxine (injection)

{{DrugProjectFormSinglePage |authorTag=Alberto Plate [1] |genericName=Pyridoxine hydrochloride |aOrAn=a |drugClass=nutritive agent of the vitamin B family |indicationType=treatment |indication=inadequate dietary intake, drug-induced deficiency, as from isoniazid (INH) or oral contraceptives, inborn errors of metabolism, e.g., vitamin B6 dependent convulsions or vitamin B6 responsive anemia. The parenteral route is indicated when oral administration is not feasible as in anorexia, nausea and vomiting, and preoperative and postoperative conditions. It is also indicated when gastrointestinal absorption is impaired. |adverseReactions=decreased folic acid, paresthesia and somnolence |blackBoxWarningTitle=TITLE |blackBoxWarningBody=Condition Name: (Content) |fdaLIADAdult======Dietary Deficiency=====

• Pyridoxine Hydrochloride Injection may be administered intramuscularly or intravenously. In cases of dietary deficiency, the dosage is 10 to 20 mg daily for 3 weeks. Follow-up treatment is recommended daily for several weeks with an oral therapeutic multivitamin preparation containing 2 to 5 mg pyridoxine. Poor dietary habits should be corrected, and an adequate, well balanced diet should be prescribed.

Vitamine B6 Dependency Syndrome

• The vitamin B6 dependency syndrome may require a therapeutic dosage of as much as 600 mg a day and a daily intake of 30 mg for life.

Drug-Induced Deficiency

• In deficiencies due to INH, the dosage is 100 mg daily for 3 weeks followed by a 30 mg maintenance dose daily.

Poisoning

• In poisoning caused by ingestion of more than 10 g of INH, an equal amount of pyridoxine should be given — 4 g intravenously followed by 1 g intramuscularly every 30 minutes.

|offLabelAdultGuideSupport======Hemopoietic stem cell transplant - Tuberculosis; Prophylaxis=====

• Dosage: 25 to 50 mg orally once daily for 9 months in combination with Isoniazid (INH) Isoniazid 5 mg/kg/day orally or intramuscularly for 9 months (ie, for 270 doses); maximum dose, 300 mg/day

|offLabelAdultNoGuideSupport======AIDS Virus Infection Associated With Pregnancy=====

Treatment and Prophylaxis of Peripheral Polyneuropathy

• Dosage: 60 mg/day for 4 weeks

Hydrazine Intoxication

• Dosage: 5 g IV diluted in 500 mL of 5% dextrose

Pregnancy Morning Sickness

• Dosage: 30 milligrams/day

|offLabelPedGuideSupport======Hemopoietic stem cell transplant - Tuberculosis; Prophylaxis=====

• Dosage: 25 to 50 mg orally once daily for 9 months in combination with Isoniazid (INH) Isoniazid 5 mg/kg/day orally or intramuscularly for 9 months (ie, for 270 doses); maximum dose, 300 mg/day

|offLabelPedNoGuideSupport======Hyperhomocysteinemia, Associated with Sickle Cell Disease=====

• Dosage: 6 mg (4.6-10.0 US 1998 RDA).

Treatment of infantile spasms with high-dosage vitamin B6

• Dosage
  • Week 1: 100 mg/day PO q24h
  • Week 2-5: 300 mg/day PO q24h

|contraindications=A history of sensitivity to pyridoxine or to any of the ingredients in Pyridoxine Hydrochloride Injection, USP is a contraindication. |warnings=This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. |clinicalTrials=Paresthesia, somnolence, and low serum folic acid levels have been reported. |drugInteractions=Pyridoxine supplements should not be given to patients receiving levodopa, because the action of the latter drug is antagonized by pyridoxine. However, this vitamin may be used concurrently in patients receiving a preparation containing both carbidopa and levodopa. |FDAPregCat=A |useInPregnancyFDA=The requirement for pyridoxine appears to be increased during pregnancy. Pyridoxine is sometimes of value in the treatment of nausea and vomiting of pregnancy. |useInNursing=The need for pyridoxine is increased during lactation. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when pyridoxine hydrochloride is administered to a nursing woman. |overdose=Pyridoxine given to animals in amounts of 3 to 4 g/kg of body weight produces convulsions and death. In man, a dose of 25 mg/kg of body weight is well tolerated. |drugBox=

Pyridoxine (injection)
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