Amikacin
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin is most often used for treating severe, hospital-acquired infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for febrile neutropenia.
Category
Aminoglycoside
US Brand Names
AMIKACIN SULFATE®, AMIKIN®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.