Clobutinol

	WikiDoc Resources for Clobutinol
Articles
Most recent articles on Clobutinol Most cited articles on Clobutinol Review articles on Clobutinol Articles on Clobutinol in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Clobutinol Images of Clobutinol Photos of Clobutinol Podcasts & MP3s on Clobutinol Videos on Clobutinol
Evidence Based Medicine
Cochrane Collaboration on Clobutinol Bandolier on Clobutinol TRIP on Clobutinol
Clinical Trials
Ongoing Trials on Clobutinol at Clinical Trials.gov Trial results on Clobutinol Clinical Trials on Clobutinol at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Clobutinol NICE Guidance on Clobutinol NHS PRODIGY Guidance FDA on Clobutinol CDC on Clobutinol
Books
Books on Clobutinol
News
Clobutinol in the news Be alerted to news on Clobutinol News trends on Clobutinol
Commentary
Blogs on Clobutinol
Definitions
Definitions of Clobutinol
Patient Resources / Community
Patient resources on Clobutinol Discussion groups on Clobutinol Patient Handouts on Clobutinol Directions to Hospitals Treating Clobutinol Risk calculators and risk factors for Clobutinol
Healthcare Provider Resources
Symptoms of Clobutinol Causes & Risk Factors for Clobutinol Diagnostic studies for Clobutinol Treatment of Clobutinol
Continuing Medical Education (CME)
CME Programs on Clobutinol
International
Clobutinol en Espanol Clobutinol en Francais
Business
Clobutinol in the Marketplace Patents on Clobutinol
Experimental / Informatics
List of terms related to Clobutinol

Clobutinol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	oral
ATC code	R05DB03 (WHO) ;
Legal status
Legal status	Withdrawn; (EU)
Identifiers
	IUPAC name (RS)-1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol;
CAS Number	14860-49-2 ;
PubChem CID	26937;
DrugBank	DB09004 ;
ChemSpider	25085 ;
UNII	1NY2IX043A;
KEGG	D07716 ;
ChEMBL	ChEMBL1474889 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H22ClNO
Molar mass	255.783 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)CC(O)(C)C(C)CN(C)C;
	InChI InChI=1S/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3 ; Key:KVHHQGIIZCJATJ-UHFFFAOYSA-N ;
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval.^[1] Clobutinol was in 2007 determined to cause cardiac arrhythmia in some patients.^[2]

Boehringer Ingelheim products containing clobutinol were voluntarily withdrawn from sale in Germany, and the rest of the world, on August 31, 2007.^[3]

The approval for Germany and the EU was revoked in 2008.^[4]

References

↑ PMID 15280442 (PMID 15280442)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
↑ "Clobutinol-haltige Arzneimittel: BfArM ordnet Widerruf der Zulassung an". BfArM (German Federal Institute for Drugs and Medical Devices). 2007-08-31. Clobutinol: BfArM orders cancellation of approval
↑ "Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications". Boehringer Ingelheim. 2007-08-31.
↑ "Cancellation of approval" (pdf). BfArM (German Federal Institute for Drugs and Medical Devices). 2008-06-06. Die Zulassungen für die o.g. Arzneimittel werden mit sofortiger Wirkung widerrufen.

Template:Cough and cold preparations

[pmid15280442-1] PMID 15280442 (PMID 15280442)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[2] "Clobutinol-haltige Arzneimittel: BfArM ordnet Widerruf der Zulassung an". BfArM (German Federal Institute for Drugs and Medical Devices). 2007-08-31. Clobutinol: BfArM orders cancellation of approval

[3] "Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications". Boehringer Ingelheim. 2007-08-31.

[4] "Cancellation of approval" (pdf). BfArM (German Federal Institute for Drugs and Medical Devices). 2008-06-06. Die Zulassungen für die o.g. Arzneimittel werden mit sofortiger Wirkung widerrufen.

[1]

[2]

[3]

[4]

Clobutinol

Overview

Side effects and withdrawal

See also

References

Navigation menu

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	oral
ATC code	R05DB03 (WHO)
Legal status
Legal status	Withdrawn _(EU)
Identifiers
IUPAC name (RS)-1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol
CAS Number	14860-49-2^Y
PubChem CID	26937
DrugBank	DB09004^N
ChemSpider	25085^Y
UNII	1NY2IX043A
KEGG	D07716^Y
ChEMBL	ChEMBL1474889^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₄H₂₂ClNO
Molar mass	255.783 g/mol
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)CC(O)(C)C(C)CN(C)C
InChI InChI=1S/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3^Y Key:KVHHQGIIZCJATJ-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Clobutinol

Overview

Side effects and withdrawal

See also

References

Navigation menu

Search