Mianserin
| File:Mianserin.svg | |
| Clinical data | |
|---|---|
| ATC code | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C18H20N2 |
| Molar mass | 264.365 |
Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. Mianserin is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. It was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.
Mianserin blocks inhibitory α2-autoreceptors on central noradrenergic nerve endings, and so may increase the amount of noradrenaline in the synaptic cleft. It may also cause agranulocytosis and aplastic anaemia.
Mianserin has been shown to increase the lifespan of the nematode C. elegans by 30%.[1] [2]
References
- ↑ Antidepressant Found To Extend Lifespan In C. elegans http://www.sciencedaily.com/releases/2007/11/071121144946.htm
- ↑ An antidepressant that extends lifespan in adult Caenorhabditis elegans http://www.nature.com/nature/journal/v450/n7169/abs/nature05991.html
de:Mianserin
it:Mianserina
sv:Mianserin
Template:WikiDoc Sources
- Pages with script errors
- Pages with broken file links
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Tetracyclic antidepressants