Nialamide

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Nialamide
File:Nialamide.svg
Clinical data
Routes of
administration		Oral, intramuscular,[1] intravenous[2]
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
ExcretionRenal[1]
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC16H18N4O2
Molar mass298.34 g/mol

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid.

Uses

Approved

Nialamide is effective for depression characterized by anergic symptoms,[3] endogenous depression,[4] and reactive depression.[5]

Unapproved/Off-Label/Investigational

Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism,[6] dermatomally distributed vitiligo,[7] irregular menstrual cycle,[8], angina,[9] cerebrovascular disorders,[10] and the prevention of streptomycin-induced deafness.[11]

Side effects

Side effects of nialamide include insomnia, vertigo, hyperhidrosis, weight gain, vomiting, tachycardia, constipation, dry mouth, upset stomach, orthostatic hypotension and decreased systolic pressure.

Tradenames

Nialamide is sold under Psicodisten®, Niaquitil®, Nialamid®, Niamidal®, Niamide®, Novazid®, Nuredal®, Niamid® (Italy, Belgium, Netherlands, England, United States),[2] Niazin®, Nyazin®, Surgex® (Italy),[1] Mygal®, Delmoneurina®, Isalizina® (Italy),[1] Espril® (Italy),[1] and Nyezin®.[3]

References and End Notes

  1. ↑ 1.0 1.1 1.2 1.3 "NIALAMIDE". BIAM Database. 2001. Retrieved August 27. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
  2. ↑ Anonymous (2001). "NIALAMIDE". Antidepresseurs. BIAM. Retrieved 27 August. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
  3. ↑ "SID 35970 -- PubChem Substance Summary - Depositor-Supplied Synonyms: All". Retrieved 25 September. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help) National Center for Biotechnology Information.
  1. ^ Benady DR, Clein LJ, Pare CM (1965). "Intramuscular nialamide in intractable depression". Diseases of the Nervous System. 26 (12): 792–4. [No abstract] PMID 5321917 List of Print Collections
  2. ^ Oules J, Cabazon (1964). "[TREATMENT OF DEPRESSIVE STATES WITH INTRAVENOUS NIAMIDE.]". Toulouse Medical. 65 (1): 1298–302. PMID 14272189. [Article in French] New York Academy of Medicine Library holding
  3. ^ Vaisberg M, McGahee CL, Radinger N, Saunders JC (1959). "Nialamide for the treatment of anergy and depression". Diseases of the Nervous System. 20 (Supplemental): 22–5. PMID 13840714. List of Library Holdings
  4. ^ Van Reeth PC, Bloch C (1960). "[Treatment of endogenous depressions by a new inhibitor of monoamine oxidase: nialamide.]". Acta Neurologica Belgica. 60 (1): 320–7. [Article in French] PMID 13841128 Harvard University Library Holding
  5. ^ Cormary M (1966). "[Use of parenteral nialamide in the treatment of reactive or neurotic depressive states]". Lyon Medical. 215 (15): 1051–62. [Article in French] PMID 5930244 List of Library Holdings
  6. ^ Bobrov AE, Shurygin AN, Krasil'nikov SB (1991). "[Effectiveness of combined use of monoamine oxidase inhibitors and psychotherapy in the treatment of chronic alcoholism]". Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova. 91 (2): 79–83. [Article in Russian] PMID 1647635 List of Library Holdings
  7. ^ Koga M (1977). "Vitiligo: a new classification and therapy". British Journal of Dermatology. 97 (3): 255–61. PMID 921895. List of Library Holdings
  8. ^ Gautray JP, Jolivet A (1976). "[Neuroendocrine investigation and therapy of the menstrual cycle disorders (author's transl)(proceedings)]". Annales d'Endocrinologie. 37 (4): 293–4. PMID 1022189. List of Library Holdings
  9. ^ Barats SS, Oranskii IE, Kartashova DI, Gorovater EN (1976). "[Comparative clinico-physiological study of the effect of several MAO inhibitors in stenocardia]". Kardiologiia. 16 (3): 138–40. [Article in Russian] No absract. PMID 1021625 List of Library Holdings
  10. ^ Mirzoian RS (1975). "[Prevention of cerebrovascular disorders with adrenergic substances]". Biulleten' Eksperimental'noi Biologii i Meditsiny. 80 (11): 50–3. [Article in Russian] PMID 1218262 List of Library Holdings
  11. ^ Semczuk B, Klonowski S, Golabek W (1974). "The protective effect of niamid on hearing in patients treated with large doses of streptomycin". Annales Universitatis Mariae Curie-Sklodowska Sectio D: Medicina. 29 (1): 193–7. No abstract. PMID 4467804 List of Library Holdings

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