Caroverine

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Caroverine
Clinical data
Routes of; administration	Oral
ATC code	A03AX11 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one;
CAS Number	23465-76-1 ;
PubChem CID	65709;
ChemSpider	59135 ;
UNII	XJ73B0K6KB;
ChEMBL	ChEMBL1729803 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H27N3O2
Molar mass	365.47 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C/1N(c3c(\N=C\1Cc2ccc(OC)cc2)cccc3)CCN(CC)CC;
	InChI InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3 ; Key:MSPRUJDUTKRMLM-UHFFFAOYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Caroverine (Spasmium, Spadon, Tinnex) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.^[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.^[1] It also has potent antioxidant effects.^[1]^[2]

Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.

↑ ^1.0 ^1.1 ^1.2 Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine". Biochemical Pharmacology. 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379.
↑ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors. 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.

v t e Skeletal Muscle relaxants (M03)
Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs)	Template:Navbox subgroup
Centrally Acting	Template:Navbox subgroup
Directly acting	Dantrolene

Clinical data

Routes of administration	Oral
ATC code	A03AX11 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
CAS Number	23465-76-1^Y
PubChem CID	65709
ChemSpider	59135^Y
UNII	XJ73B0K6KB
ChEMBL	ChEMBL1729803^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₂H₂₇N₃O₂
Molar mass	365.47 g/mol
3D model (JSmol)	Interactive image
SMILES O=C/1N(c3c(\N=C\1Cc2ccc(OC)cc2)cccc3)CCN(CC)CC
InChI InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3^Y Key:MSPRUJDUTKRMLM-UHFFFAOYSA-N^Y
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