Dexfenfluramine

Dexfenfluramine

Clinical data
ATC code	A08AA04 (WHO)
Legal status
Legal status	Schedule IV (US DEA)
Pharmacokinetic data
Protein binding	36%
Elimination half-life	17-20 hours
Identifiers
IUPAC name N-Ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
CAS Number	3239-44-9
PubChem CID	3337
DrugBank	APRD00648
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H16F3N
Molar mass	231.257 g/mol

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Clinical Trials
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Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. After it was removed in the US, dexfenfluramine was also pulled out in other global markets. It was later superseded by sibutramine, which is a safer alternative to both dexfenfluramine and fenfluramine.

The drug was manufactured by Interneuron Pharmaceuticals and marketed by Wyeth-Ayerst Laboratories. It is the enantiomer of levofenfluramine.

See also

• Fen-phen

References

• FDA Announces Withdrawal Fenfluramine and Dexfenfluramine (Fen-Phen)