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• Klebsiella rhinoscleromatis Return to Top

• 1. Rhinoscleroma

• Preferred regimen (1): Ciprofloxacin 500–750 mg PO bid for 2–3 months OR Levofloxacin 750 mg PO qd for 2–3 months
• Preferred regimen (2): Trimethoprim-Sulfamethoxazole 1 DS tab PO bid for 3 months AND Rifampicin 300 mg PO bid for 3 months
• Alternative regimen: Tetracycline OR Streptomycin OR Doxycycline OR Ceftriaxone OR Ofloxacin
• Note (1): The optimal duration of antimicrobial therapy remains unclear. A 6-week to 6-month cours of antibiotics until histology exams and cultures are negative may be required.
• Note (2): Use of topical antibiotics such as Acriflavinium and Rifampin ointment has been reported with resolution of symptoms.