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1. Bacteremia^[1]

1.1 Ampicillin or Penicillin susceptible

Preferred regimen (1): Ampicillin 2 g IV q4-6h
Preferred regimen (2): Ampicillin 2 g IV q4-6h AND Gentamicin 1 mg/kg q8h

1.2 Ampicillin resistant and vancomycin susceptible or Penicillin allergy

Preferred regimen (1): Vancomycin 15 mg/kg IV q12h AND Gentamicin 1 mg/kg q8h
Preferred regimen (2): Linezolid 600 mg q12h
Preferred regimen (3): Daptomycin 6 mg/kg/day.

1.3 Ampicillin and Vancomycin resistant

Preferred regimen (1): Linezolid 600 mg q12h
Preferred regimen (2): Daptomycin 6 mg/kg/day IV

2. Endocarditis^[2]^[3]

2.1 Endocarditis in Adults

2.1.1 Strains Susceptible to Penicillin, Gentamicin, and Vancomycin

Preferred regimen: (Ampicillin 12 g/day IV for 4–6weeks OR Aqueous crystalline penicillin G sodium 18–30 MU/day IV for 4–6weeks) AND Gentamicin sulfate 3 mg/kg/day IV/IM for 4–6 weeks
Note : In case of native valve endocarditis, 4-wk therapy recommended for patients with symptoms of illness ≤3 months and 6-week therapy recommended for patients with symptoms >3 months and prosthetic valve or other prosthetic cardiac material a minimum of 6 week of therapy recommended
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6 weeks AND Gentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.2 Strains Susceptible to Penicillin, Streptomycin, and Vancomycin and Resistant to Gentamicin

Preferred regimen: (Ampicillin 12 g/day IV for 4–6 weeks ORAqueous crystalline penicillin G sodium 24 MU/day IV for 4–6weeks)ANDStreptomycin sulfate 15 mg/kg/day IV/IM for 4–6weeks
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV 6weeks ANDStreptomycin sulfate 15 mg/kg per 24 h IV/IM for 6weeks

2.1.3 Strains Resistant to Penicillin and Susceptible to Aminoglycoside and Vancomycin

2.1.3.1 β Lactamase–producing strain

Preferred regimen: Ampicillin-sulbactam 12 g/day IV for 6weeks ANDGentamicin sulfate 3 mg/kg/day IV/IM 6weeks
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6weeks ANDGentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.3.2 Intrinsic penicillin resistance

Preferred regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6weeks ANDGentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.4 Strains Resistant to Penicillin, Aminoglycoside, and Vancomycin

Preferred regimen (1): (Imipenem ORCilastatin 2 g/day IV for ≥ 8weeks ANDAmpicillin 12 g/day IV for ≥ 8weeks)
Preferred regimen (2): (Ceftriaxone sodium 4 g/day IV/IM for ≥ 8weeks ANDAmpicillin 12 g/day IV for ≥ 8weeks)

2.2 Endocarditis in Pediatrics

2.2.1 Strains Susceptible to Penicillin, Gentamicin, and Vancomycin

Preferred regimen: (Ampicillin 300 mg/kg/day IV for 4–6weeks ORPenicillin 300,000 U/kg/day IV for 4–6 weeks) ANDGentamicin 3 mg/kg q24h IV/IM 4–6weeks
Note : In case of native valve endocarditis, 4-wk therapy recommended for patients with symptoms of illness ≤3 months and 6-wk therapy recommended for patients with symptoms >3 months and prosthetic valve or other prosthetic cardiac material a minimum of 6 wk of therapy recommended
Alternate regimen : Vancomycin 40 mg/kg/day IV for 6weeks ANDGentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.2 Strains Susceptible to Penicillin, Streptomycin, and Vancomycin and Resistant to Gentamicin

Preferred regimen: (Ampicillin 300 mg/kg/day IV for 4–6weeks ORPenicillin 300,000 U/kg/day IV for 4–6weeks) ANDStreptomycin 20–30 mg/kg/day IV/IM for 4–6 weeks
Alternate regimen: Vancomycin hydrochloride 40 mg/kg/day IV for 6weeks ANDStreptomycin sulfate 15 mg/kg/day IV/IM for 6weeks

2.2.3 Strains Resistant to Penicillin and Susceptible to Aminoglycoside and Vancomycin

2.2.3.1 β Lactamase–producing strain

Preferred regimen: Ampicillin-sulbactam 300 mg/kg/day IV for 6weeks ANDGentamicin 3 mg/kg/day IV/IM for 6weeks
Alternate regimen: Vancomycin 40 mg/kg/day IV for 6weeks ANDGentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.3.2 Intrinsic penicillin resistance

Preferred regimen: Vancomycin 40 mg/kg/day IV ANDGentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.4 Strains Resistant to Penicillin, Aminoglycoside, and Vancomycin

Preferred regimen: Imipenem/Cilastatin 60–100 mg/kg/day IV for ≥ 8weeks ANDAmpicillin 300 mg/kg/day IV for ≥ 8weeks
Alternate regimen: Ceftriaxone 100 mg/kg/day IV/IM ANDAmpicillin 300 mg/kg/day IV for ≥ 8weeks

3. Meningitis^[4]::*3.1 Ampicillin susceptible

Preferred regimen: Ampicillin 12 g/day IV q4h ANDGentamicin 5 mg/kg/day IV q8h

3.2 Ampicillin resistant

Preferred regimen: Vancomycin 30–45 mg/kg/day IV q8–12h ANDGentamicin 5 mg/kg/day IV q8h

3.3 Ampicillin and vancomycin resistant

Preferred regimen: Linezolid 600 mg IV q12h

4. Urinary tract infections ^[5]

Preferred regimen (1): Nitrofurantoin 100 mg PO q6h for 5 days
Preferred regimen (2): Fosfomycin 3 g PO single dose
Preferred regimen (3): Amoxicillin 875 mg to 1 g PO q12h for 5 days

5. Intra abdominal or Wound infections ^[6]

Preferred regimen(1): Penicillin
Preferred regimen(2): Ampicillin
Alternative regimen(Penicillin allergy or high-level Penicillin resistance): Vancomycin
Alternative regimen(For complicated skin-skin structure and intra-abdominal infection): Tigecycline 100 mg IV single dose and 50 mg IV q12h

Enterococcus faecium

1. Bacteremia^[7]

1.1 Ampicillin or Penicillin susceptible

Preferred regimen (1): Ampicillin 2 g IV q4-6h
Preferred regimen (2): Ampicillin 2 g IV q4-6h AND Gentamicin 1 mg/kg q8h

1.2 Ampicillin resistant and vancomycin susceptible or Penicillin allergy

Preferred regimen (1): Vancomycin 15 mg/kg IV q12h AND Gentamicin 1 mg/kg q8h
Preferred regimen (2): Linezolid 600 mg q12h
Preferred regimen (3): Daptomycin 6 mg/kg/day.

1.3 Ampicillin and Vancomycin resistant

Preferred regimen (1): Linezolid 600 mg q12h
Preferred regimen (2): Daptomycin 6 mg/kg/day IV

2. Endocarditis

2.1 Endocarditis in Adults

2.1.1 Strains Susceptible to Penicillin, Gentamicin, and Vancomycin

Preferred regimen: (Ampicillin 12 g/day IV for 4–6weeks OR Aqueous crystalline penicillin G sodium 18–30 MU/day IV for 4–6weeks) AND Gentamicin sulfate 3 mg/kg/day IV/IM for 4–6 weeks
Note : In case of native valve endocarditis, 4-week therapy recommended for patients with symptoms of illness ≤3 months and 6-week therapy recommended for patients with symptoms >3 months and prosthetic valve or other prosthetic cardiac material a minimum of 6 week of therapy recommended
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6 weeks AND Gentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.2 Strains Susceptible to Penicillin, Streptomycin, and Vancomycin and Resistant to Gentamicin

Preferred regimen: (Ampicillin 12 g/day IV for 4–6 weeks ORAqueous crystalline penicillin G sodium 24 MU/day IV for 4–6weeks)ANDStreptomycin sulfate 15 mg/kg/day IV/IM for 4–6weeks
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV 6weeks AND Streptomycin sulfate 15 mg/kg per 24 h IV/IM for 6weeks

2.1.3 Strains Resistant to Penicillin and Susceptible to Aminoglycoside and Vancomycin

2.1.3.1 β Lactamase–producing strain

Preferred regimen: Ampicillin-sulbactam 12 g/day IV for 6weeks AND Gentamicin sulfate 3 mg/kg/day IV/IM 6weeks
Alternate regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6weeks AND Gentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.3.2 Intrinsic penicillin resistance

Preferred regimen: Vancomycin hydrochloride 30 mg/kg/day IV for 6weeks AND Gentamicin sulfate 3 mg/kg/day IV/IM for 6weeks

2.1.4 Strains Resistant to Penicillin, Aminoglycoside, and Vancomycin

Preferred regimen(1): Linezolid 1200 mg/day IV/PO ≥8weeks
Preferred regimen(2): Quinupristin-Dalfopristin 22.5 mg/kg/day IV ≥8weeks

2.2 Endocarditis in Pediatrics

2.2.1 Strains Susceptible to Penicillin, Gentamicin, and Vancomycin

Preferred regimen: (Ampicillin 300 mg/kg/day IV for 4–6weeks OR Penicillin 300,000 U/kg/day IV for 4–6 weeks) ANDGentamicin 3 mg/kg q24h IV/IM 4–6weeks
Note : In case of native valve endocarditis, 4-week therapy recommended for patients with symptoms of illness ≤3 months and 6-week therapy recommended for patients with symptoms >3 months and prosthetic valve or other prosthetic cardiac material a minimum of 6 week of therapy recommended
Alternate regimen : Vancomycin 40 mg/kg/day IV for 6weeks AND Gentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.2 Strains Susceptible to Penicillin, Streptomycin, and Vancomycin and Resistant to Gentamicin

Preferred regimen: (Ampicillin 300 mg/kg/day IV for 4–6weeks OR Penicillin 300,000 U/kg/day IV for 4–6weeks) ANDStreptomycin 20–30 mg/kg/day IV/IM for 4–6 weeks
Alternate regimen: Vancomycin hydrochloride 40 mg/kg/day IV for 6weeks ANDStreptomycin sulfate 15 mg/kg/day IV/IM for 6weeks

2.2.3 Strains Resistant to Penicillin and Susceptible to Aminoglycoside and Vancomycin

2.2.3.1 β Lactamase–producing strain

Preferred regimen: Ampicillin-sulbactam 300 mg/kg/day IV for 6weeks AND Gentamicin 3 mg/kg/day IV/IM for 6weeks
Alternate regimen: Vancomycin 40 mg/kg/day IV for 6weeks AND Gentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.3.2 Intrinsic penicillin resistance

Vancomycin 40 mg/kg/day IV AND Gentamicin 3 mg/kg/day IV/IM for 6weeks

2.2.4 Strains Resistant to Penicillin, Aminoglycoside, and Vancomycin

Preferred regimen(1): Linezolid 30 mg/kg/day IV/PO ≥ 8weeks
Preferred regimen(2): Quinupristin-Dalfopristin22.5 mg/kg/day IV ≥ 8weeks

3. Meningitis^[4]

3.1 Ampicillin susceptible

Preferred regimen: Ampicillin 12 g/day IV q4h AND Gentamicin 5 mg/kg/day IV q8h

3.2 Ampicillin resistant

Preferred regimen: Vancomycin 30–45 mg/kg/day IV q8–12h AND Gentamicin 5 mg/kg/day IV q8h

3.3 Ampicillin and vancomycin resistant

Preferred regimen: Linezolid 600 mg IV q12h

4. Urinary tract infections^[8]

Preferred regimen (1): Nitrofurantoin 100  mg PO q6h for 5 days
Preferred regimen (2): Fosfomycin 3 g PO single dose
Preferred regimen (3): Amoxicillin 875 mg to 1 g PO q12h for 5 days

5. Intra abdominal or Wound infections ^[9]

Preferred regimen(1): Penicillin
Preferred regimen(2): Ampicillin
Alternative regimen(Penicillin allergy or high-level Penicillin resistance): Vancomycin
Alternative regimen(For complicated skin-skin structure and intra-abdominal infection): Tigecycline 100 mg IV single dose and 50 mg IV q12h

↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
↑ Baddour, LM.; Wilson, WR.; Bayer, AS.; Fowler, VG.; Bolger, AF.; Levison, ME.; Ferrieri, P.; Gerber, MA.; Tani, LY. (2005). "Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America". Circulation. 111 (23): e394–434. doi:10.1161/CIRCULATIONAHA.105.165564. PMID 15956145. Unknown parameter |month= ignored (help)
↑ "Infective Endocarditis Diagnosis, Antimicrobial Therapy, and Management of Complications A Statement for Healthcare Professionals From the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association".
↑ ^4.0 ^4.1 Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM; et al. (2004). "Practice guidelines for the management of bacterial meningitis". Clin Infect Dis. 39 (9): 1267–84. doi:10.1086/425368. PMID 15494903.
↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

[1] Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

[Baddour-2005-2] Baddour, LM.; Wilson, WR.; Bayer, AS.; Fowler, VG.; Bolger, AF.; Levison, ME.; Ferrieri, P.; Gerber, MA.; Tani, LY. (2005). "Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America". Circulation. 111 (23): e394–434. doi:10.1161/CIRCULATIONAHA.105.165564. PMID 15956145. Unknown parameter |month= ignored (help)

[3] "Infective Endocarditis Diagnosis, Antimicrobial Therapy, and Management of Complications A Statement for Healthcare Professionals From the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association".

[pmid15494903-4] 4.0 ^4.1 Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM; et al. (2004). "Practice guidelines for the management of bacterial meningitis". Clin Infect Dis. 39 (9): 1267–84. doi:10.1086/425368. PMID 15494903.

[5] Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.

[6] Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

[7] Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

[8] Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.

[9] Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

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