Dengue fever causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Dengue fever is caused by one of four different but related Dengue fever viruses. Aedes aegypti is the principal mosquito vector of dengue fever viruses.[1]
Dengue Fever Virus
- Dengue fever virus (DENV) is an RNA virus of the family Flaviviridae; genus Flavivirus.
- Other members of the same genus include yellow fever virus, West Nile virus, St. Louis encephalitis virus, japanese encephalitis virus, tick-borne encephalitis, Kyasanur Forest disease virus, and Omsk hemorrhagic fever virus.
- Most are transmitted by arthropods (mosquitoes or ticks), and are therefore also referred to as arboviruses (arthropod-borne viruses).
- The dengue virus genome contains about 11,000 nucleotide bases, which code for the three different types of protein molecules (C, prM and E) that form the virus particle and seven other types of protein molecules (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) that are only found in infected host cells and are required for replication of the virus.
- There are five strains of the virus, of which the first four are referred to as DENV-1, DENV-2, DENV-3 and DENV-4.
- The distinctions between the serotypes is based on the their antigenicity.
Gallery
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Aedes mediovittatus mosquito is a vector in the transmission of Dengue Fever. From Public Health Image Library (PHIL). [2]
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Illustration identifying the pecten on the terminal abdominal segment of an Aedes mosquito larva, vector of Dengue transmission. From Public Health Image Library (PHIL). [2]
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Red blood meal visible through her now transparent abdomen of female Aedes aegypti mosquito after leaving host’s skin surface. From Public Health Image Library (PHIL). [2]
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Aedes aegypti female was from a strain of mosquitoes named LVP-IB12. From Public Health Image Library (PHIL). [2]