Mycobacterium chelonae
| style="background:#Template:Taxobox colour;"|Mycobacterium chelonae | ||||||||||||||
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| style="background:#Template:Taxobox colour;" | Scientific classification | ||||||||||||||
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| Mycobacterium chelonae Bergey et al. 1923, ATCC 35752 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Mycobacterium chelonae is a species of the phylum actinobacteria (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus mycobacterium.
Causes
- Mycobacterium chelonae is a rapidly growing mycobacterium, that is found all throughout the environment including sewage and tap water.
- It can occasionally cause opportunistic infections of humans. It is grouped in Runyon group IV.
- Type strain: strain CM 6388 = ATCC 35752 = CCUG 47445 = CIP 104535 = DSM 43804 = JCM 6388 = NCTC 946.
Epidemiology
- On average, 2 cases of nonpulmonary M. chelonae infection are reported in South Australia each year.[1]
Treatment
Antimicrobial Regimen
- 1. Localized infections [2]
- Preferred regimen: Clarithromycin 500 mg PO BID
- Alternative regimen: Azithromycin
- 2. Disseminated or extensive disease
- 2.1 monotherapy
- Preferred regimen: Clarithromycin 500 mg PO BID
- 2.2 multidrug therapy
- Preferred regimen: Clarithromycin 500 mg PO BID AND Tobramycin 5 mg IV/kg/day PO OR Imipenem 0.5-1 g IV q6h OR Linezolid 600 mg IV/PO BID for 4-8 weeks
- Alternative regimen: Moxifloxacin 400 mg PO qd AND Linezolid 600 mg PO BID
- Note (1): During initial treatment, multidrug therapy may prevent development of acquired resistance
- Note (2): Total treatment duration is 6 months
* 3. Keratitis (LASIK-related)
- Preferred regimen: Clarithromycin 500 mg PO BID AND topicals (Tobramycin 0.3%, 2 gtts q4h AND Gatifloxacin 0.3%, 1 gtt q4h OR Moxifloxacin 0.5%, 1 gtt q4h
References
- ↑ Ivan, Mihaela; Dancer, Craig; Koehler, Ann P.; Hobby, Michaela; Lease, Chris (2013). "Mycobacterium chelonae Abscesses Associated with Biomesotherapy, Australia, 2008". Emerging Infectious Diseases. 19 (9). doi:10.3201/eid1909.120898. PMC 3810901. PMID 23968779.
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.