Sandbox Turky3
Aspergillosis
Invasive pulmonary aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Invasive sinus aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Tracheobronchial aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Chronic necrotizing pulmonary aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Aspergillosis of the CNS
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)