Astrocytoma historical perspective
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Overview
Historical Perspective
- Astrocytoma was the first glioma tumors to be described.
- Astrocytoma was first explained as glioma duram by Virchow in 1840.
- Astrocytoma was decribed as spider cell glioma by T.Simon in 1874.
- Astrocytoma was also described as astroma by M von Lenhossek in 1895.
- Other names given earlier were as follows.
- Amoebiod giant cell glioma in 1918 by O Lotmar.
- Fibrillary, protoplasmic astrocytoma and astroblastoma in 1926 by Baley and Cushing
- Afibrillary and gigantocellular astrocytoma in 1932 by Roussy and Oberling
- Piloid, gemistocytic and diffuse astrocytoma in 1932 by Penfield [1]
- Cerebellar astrocytoma was first described by Harvey Cushing in 1931.[2]
- Histological description of astrocytoma was first given by Bergstrand in 1932.[3]
Society and culture
Astrocytoma plays an important role in the plot of the film Phenomenon (1996). The lead character, George Malley (John Travolta) develops the tumor, but at first it gives him genius-level intelligence and special powers, and this and other symptoms create the impression that he has been influenced by extraterrestrials, until the tumor is discovered by tests. The tumor later kills him. The type of tumor and the fatal result are factual, but the special powers and intelligence are fictional plot devices.
Notable cases
In March 1990, prolific United States Republican Party political strategist Lee Atwater was diagnosed with astrocytoma after a tumor was found in his right parietal lobe. After undergoing radiation therapy (including the then-new implant radiation treatment), Atwater died the following year at the age of 40.[4]
Long-time U.S. Senator Ted Kennedy (D-MA) died of malignant glioma.[5] The course of his illness suggests GBM. After his initial seizure and subsequent diagnosis in May 2008, he chose aggressive treatment and survived 15 months.
2001 World Rally Championship winner Richard Burns was diagnosed with it after suffering a blackout while traveling to the 2003 Wales Rally GB. He died on 25 November 2005, four years to the day after winning the WRC Championship
Doctors diagnosed composer George Gershwin with a glioblastoma multiforme in 1937. However, recent studies indicate that this diagnosis may have been incorrect. Some believe it may have been a Pilocytic astrocytoma.
University of Texas sniper Charles Whitman who killed multiple people during a mass murder event in 1966 was diagnosed with astrocytoma post-mortem. The Connally Commission investigating the shooting concluded the tumor "conceivably could have contributed to his inability to control his emotions and actions."[6]
Mo Mowlam (Secretary of State for Northern Ireland May 1997 - October 1999) - had a mild form of glioma on left frontal lobe.[7]
Dan Quisenberry (Major League pitcher) was diagnosed with grade IV astrocytoma in January 1998. He died in 1998 in Leawood, Kansas.[8]
Robert Moog (American pioneer of electronic music) was diagnosed with grade IV astrocytoma on April 28, 2005. He died on August 21, 2005 in Asheville, North Carolina.
References
- ↑ lch, Klaus (1986). Brain Tumors Their Biology and Pathology. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 978-3-642-68180-6.
- ↑ Collins VP, Jones DT, Giannini C (2015). "Pilocytic astrocytoma: pathology, molecular mechanisms and markers". Acta Neuropathol. 129 (6): 775–88. doi:10.1007/s00401-015-1410-7. PMC 4436848. PMID 25792358.
- ↑ lch, Klaus (1986). Brain Tumors Their Biology and Pathology. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 978-3-642-68178-3.
- ↑ Brady, John (December 1, 1996). "I'm Still Lee Atwater", The Washington Post, retrieved 2010-04-11.
- ↑ "Kennedy fought aggressive cancer". CNN. August 26, 2009. Retrieved 2010-02-27.
- ↑ Waring, Thomas R., ed. "Jury Blames Tumor For Killings: Doctor Says Whitman Unaffected"" The News and Courier [Charleston] 05 Aug. 1966: 9B. Print.
- ↑ Langdon, Julia (17 January 2010). "Mo Mowlam told PM brain tumour was benign to get job as Cabinet minister". Daily Mail. London.
- ↑ Henderson, Heather (1999). "Dan Quisenberry - In His Own Words" The 1999 Big Bad Baseball Annual. Retrieved June 24, 2013.