Fibroadenoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Depending on the amount and the relationship between these two components, there are two main histological features: intracanalicular and pericanalicular. Often, both types are found in the same tumor. Intracanalicular fibroadenoma: stromal proliferation predominates and compresses the ducts, which are irregular, reduced to slits. Pericanalicular fibroadenoma: fibrous stroma proliferates around the ductal spaces, so that they remain round or oval, on cross section. The basement membrane is intact. 1
Macroscopically
The tumor is round, elastic, nodular, and encapsulated (well circumscribed); on cut surface it is grey-white.
Microscopically
The epithelial proliferation describes duct-like spaces surrounded by a fibroblastic stroma. The proliferated epithelium is typical.