Diffuse large B cell lymphoma classification
|
Diffuse large B cell lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Diffuse large B cell lymphoma classification On the Web |
|
American Roentgen Ray Society Images of Diffuse large B cell lymphoma classification |
|
Directions to Hospitals Treating Diffuse large B cell lymphoma |
|
Risk calculators and risk factors for Diffuse large B cell lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diffuse large B cell lymphoma may be classified into variants, subgroups, subtypes, and entities based on the World Health Organization Classification (WHO).
Classification
Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,[1] many of which cannot be separated from one another by well-defined and widely accepted criteria.
The World Health Organization (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the
- Location of the tumor
- Presence of other cells within the tumor (such as T cells)
- Other illnesses related to diffuse large B-cell lymphoma.
- One of these well-defined groupings of particular note is Primary mediastinal B-cell lymphoma, which arises within the thymus or mediastinal lymph nodes.
Diffuse large B-cell lymphoma, not otherwise specified
- When a case of Diffuse large B-cell lymphoma does not conform to any of the well-defined subtypes, and is also not considered unclassifiable.
- The majority of Diffuse large B-cell lymphoma cases fall into this category.
- Much research has been devoted to separating this still-heterogeneous group; such distinctions are usually made along lines of
- cellular morphology
- gene expression
- immunohistochemical properties.
Diffuse large B-cell lymphoma (DLBCL): variants, subgroups, subtypes, and entities based on the World Health Organization Classification (WHO)
DLBCL, not otherwise specified (DLBCL, NOS)
- Common morphological variants
- Centroblastic
- Immunoblastic
- Anaplastic
- Rare morphological variants
- Molecular subgroups
- Germinal center B-cell-like (GCB)
- Activated B-cell-like (ABC)
- Immunohistochemical subgroups
- CD5-positive DLBCL
- Germinal center B-cell-like (GCB)
- Non-germinal center B-cell-like (non-GCB)
DLBCL subtypes
- T-cell-/histiocyte-rich large B-cell lymphoma
- Primary DLBCL of the central nervous system
- Primary cutaneous DLBCL
- Leg type EBV-positive DLBCL of the elderly
Other lymphomas of large B-cells
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular large B-cell lymphoma
- DLBCL associated with chronic inflammation
- Lymphomatoid granulomatosis
- ALK-positive LBCL
- Plasmablastic lymphoma
- Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
- Primary effusion lymphoma
Borderline cases B-cell lymphoma
- Unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma B-cell lymphoma,
- Unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
References
- ↑ Alizadeh, Ash A.; Eisen, Michael B.; Davis, R. Eric; Ma, Chi; Lossos, Izidore S.; Rosenwald, Andreas; Boldrick, Jennifer C.; Sabet, Hajeer; Tran, Truc; Yu, Xin; Powell, John I.; Yang, Liming; Marti, Gerald E.; Moore, Troy; Hudson, James; Lu, Lisheng; Lewis, David B.; Tibshirani, Robert; Sherlock, Gavin; Chan, Wing C.; Greiner, Timothy C.; Weisenburger, Dennis D.; Armitage, James O.; Warnke, Roger; Levy, Ronald; Wilson, Wyndham; Grever, Michael R.; Byrd, John C.; Botstein, David; et al. (2000). "Distinct types of diffuse large B-cell lymphoma identified by gene expression
profiling". Nature. 403 (6769): 503–11. Bibcode:2000Natur.403..503A. doi:10.1038/35000501. PMID 10676951. line feed character in
|title=at position 78 (help)