Dermatofibrosarcoma protuberans

	WikiDoc Resources for Dermatofibrosarcoma protuberans
Articles
Most recent articles on Dermatofibrosarcoma protuberans Most cited articles on Dermatofibrosarcoma protuberans Review articles on Dermatofibrosarcoma protuberans Articles on Dermatofibrosarcoma protuberans in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Dermatofibrosarcoma protuberans Images of Dermatofibrosarcoma protuberans Photos of Dermatofibrosarcoma protuberans Podcasts & MP3s on Dermatofibrosarcoma protuberans Videos on Dermatofibrosarcoma protuberans
Evidence Based Medicine
Cochrane Collaboration on Dermatofibrosarcoma protuberans Bandolier on Dermatofibrosarcoma protuberans TRIP on Dermatofibrosarcoma protuberans
Clinical Trials
Ongoing Trials on Dermatofibrosarcoma protuberans at Clinical Trials.gov Trial results on Dermatofibrosarcoma protuberans Clinical Trials on Dermatofibrosarcoma protuberans at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Dermatofibrosarcoma protuberans NICE Guidance on Dermatofibrosarcoma protuberans NHS PRODIGY Guidance FDA on Dermatofibrosarcoma protuberans CDC on Dermatofibrosarcoma protuberans
Books
Books on Dermatofibrosarcoma protuberans
News
Dermatofibrosarcoma protuberans in the news Be alerted to news on Dermatofibrosarcoma protuberans News trends on Dermatofibrosarcoma protuberans
Commentary
Blogs on Dermatofibrosarcoma protuberans
Definitions
Definitions of Dermatofibrosarcoma protuberans
Patient Resources / Community
Patient resources on Dermatofibrosarcoma protuberans Discussion groups on Dermatofibrosarcoma protuberans Patient Handouts on Dermatofibrosarcoma protuberans Directions to Hospitals Treating Dermatofibrosarcoma protuberans Risk calculators and risk factors for Dermatofibrosarcoma protuberans
Healthcare Provider Resources
Symptoms of Dermatofibrosarcoma protuberans Causes & Risk Factors for Dermatofibrosarcoma protuberans Diagnostic studies for Dermatofibrosarcoma protuberans Treatment of Dermatofibrosarcoma protuberans
Continuing Medical Education (CME)
CME Programs on Dermatofibrosarcoma protuberans
International
Dermatofibrosarcoma protuberans en Espanol Dermatofibrosarcoma protuberans en Francais
Business
Dermatofibrosarcoma protuberans in the Marketplace Patents on Dermatofibrosarcoma protuberans
Experimental / Informatics
List of terms related to Dermatofibrosarcoma protuberans

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm of the dermis layer of the skin, and is classified as a sarcoma. In many respects, the disease behaves as a benign tumor, but in 2-5% of cases it can metastasize, so it should be considered to have malignant potential.

Over 95% of DFSP tumors have the chromosomal translocation t(17;22). The translocation fuses the collagen gene (COL1A1) with the platelet-derived growth factor gene. The fibroblast, the cell of origin of this tumor, expresses the fusion gene in the belief that it is collagen. However the resulting fusion protein is processed into mature platelet-derived growth factor which is a potent growth factor. Fibroblasts contain the receptor for this growth factor. Thus the cell "thinks" it is producing a structural protein, but in fact produces a self-stimulatory growth signal. The cell divides rapidly and a tumor forms.