Ganglioneuroma pathophysiology
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Ganglioneuroma Microchapters |
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Ganglioneuroma pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Gross Pathology
- Ganglioneuromas are solid, firm tumors that are typically white when seen with the naked eye
- Gangliocytoma is commonly located in the following regions:[1]
- Abdomen (most common)
- Adrenal gland
- Paraspinal retroperitoneum
- Posterior mediastinum
- Neck
Microscopic Pathology
- Ganglioneuromas are derived from the primordial neural crest cells, which are undifferentiated cells of the sympathetic nervous system.
- Ganglioneuromas are fully differentiated neuronal tumors that do not contain immature elements.
- They are composed of ganglion cells, schwann cells and fibrous tissue.
Videos
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Associated Conditions
- Multiple endocrine neoplasia type IIb: particularly with mucosal ganglioneuromas
References
- ↑ Pathology of ganglioneuroma. Dr Bruno Di Muzio and Dr Yuranga Weerakkody et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioneuroma