21-hydroxylase deficiency secondary prevention
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency Microchapters |
Differentiating Congenital adrenal hyperplasia due to 21-hydroxylase deficiency from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Continued monitoring of hormone balance and careful readjustment of glucocorticoid dose is helpful in controlling fertility and preventing adrenal crisis.
Secondary Prevention
Preventing hyperandrogenism and optimizing fertility
Continued monitoring of hormone balance and careful readjustment of glucocorticoid dose is helpful in controlling fertility, but as a group, women with congenital adrenal hyperplasia have a lower fertility rate.
Preventing adrenal crisis
To prevent adrenal crisis, all persons taking replacement glucocorticoids are taught to increase their doses in the event of illness, surgery, severe injury, or severe exhaustion. More importantly, they are taught that vomiting warrants an injection within hours of hydrocortisone (e.g., SoluCortef) or other glucocorticoid. This recommendation applies to both children and adults. Because young children are more susceptible to vomiting illnesses than adults, pediatric endocrinologists usually teach parents how to give hydrocortisone injections.