DRESS syndrome other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Other diagnostic studies for DRESS syndrome include elevated anti-HHV-6 IgG antibody, positive lymphocyte activation test, patch testing, and rechallenging of the suspected drug.
Other Diagnostic Studies
Anti-HHV-6 Antibody
- Herpes virus reactivation is common among patients with DRESS syndrome and may occur in approximately 80% of cases.[1]
- Elevated anti-HHV-6 IgG antibody is thought to be a useful diagnostic test when DRESS syndrome is suspected.[1]
Lymphocyte Activation Test
- The lymphocyte activation test is characterized by a low sensitivity and low specificity for DRESS syndrome.[2]
- The test may be falsely negative during the acute phase of DRESS syndrome.[2]
Patch Testing
- The diagnostic efficacy of patch testing is still controversial.
- Patch testing has yielded variable results and is presumed to be effective only when the suspected triggering agent is an anticonvulsant.[3] The efficacy of patch testing requires further validation.
Rechallenge Suspected Drug
- The approach has been used in other drug eruptions, but it has not been validated as a diagnostic strategy for DRESS syndrome given the potential life-threatening complications of the disease.[4]
References
- ↑ 1.0 1.1 Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.
- ↑ 2.0 2.1 Kano Y, Hirahara K, Mitsuyama Y, Takahashi R, Shiohara T (2007). "Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption". Allergy. 62 (12): 1439–44. doi:10.1111/j.1398-9995.2007.01553.x. PMID 17983378.
- ↑ Santiago F, Gonçalo M, Vieira R, Coelho S, Figueiredo A (2010). "Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS)". Contact Dermatitis. 62 (1): 47–53. doi:10.1111/j.1600-0536.2009.01659.x. PMID 20136879.
- ↑ Choudhary S, McLeod M, Torchia D, Romanelli P (2013). "Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome". J Clin Aesthet Dermatol. 6 (6): 31–7. PMC 3718748. PMID 23882307.