Acoustic neuroma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Acoustic neuroma may be classified into three subtypes based MRI scan, and into four subtypes based on microscopic histopathology.[1]
Classification
Based on the MRI scan, acoustic neuromas can be classified into three subtypes:
- Entirely intracanalicular: The entire tumor is completely within the bony canal.
- Intracranial extension without brain stem distortion.
- Intracranial extension with brain stem distortion.
Based on microscopic histopathology, acoustic neuroma can be classified into four subtypes:[2]
- Conventional schwannoma
- Cellular schwannoma
- Plexiform schwannoma
- Melanotic schwannoma
- Conventional schwannoma: It is the most common.
- Cellular schwannoma: It may mimic malignant peripheral nerve sheath tumor.
- Plexiform schwannoma: It may mimic malignant peripheral nerve sheath tumor if cellular- especially in childhood.
Plexiform schwannoma with high magnifaction - Melanotic schwannoma: It may be confused with melanoma.
Psammomatous melanotic schwannoma
It is associated with psammomatous form (psammomatous melanotic schwannoma) and with a heritable disorder (Carney complex). The Carney complex, also known as Carney syndrome, NAME syndrome and LAMB syndrome, is a bunch of things that occur together due to some genetic problem. It consists of:
- Cutaneous lentigines
- Myxomas (skin (subcutaneous), subcutanous, heart).
- Endocrine neoplasms[3]
References
- ↑ "Libre Pathology schwannoma acoustic neuroma subtypes".
- ↑ Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM (2003). "The pathobiologic spectrum of Schwannomas". Histol Histopathol. 18 (3): 925–34. PMID 12792904.
- ↑ "Libre Pathology schwannoma acoustic neuroma subtypes".