Tumor lysis syndrome diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
The diagnosis of tumor lysis syndrome is based on the Cairo–Bishop criteria, which includes uric acid, potassium, phosphorous, and calcium.[1]
Diagnostic Criteria
The diagnosis of tumor lysis syndrome is based on the Cairo–Bishop criteria:[1]
- Laboratory tumor lysis syndrome: abnormality in two or more of the following within 3 days before or 7 days after starting chemotherapy:
- Hyperuricemia ≥ 476 μmol/l
- Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
- Hyperkalemia ≥ 6·0 mmol/l
- Hypocalcemia ≤ 1·75 mmol/l
- Clinical tumor lysis syndrome: laboratory tumor lysis syndrome plus one or more of the following:
- Increase serum creatinine (1.5 times upper normal limit)
- Cardiac arrhythmia
- Sudden death
- Seizure
References
- ↑ 1.0 1.1 Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.