Medulloblastoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Medulloblastoma may be classified into several subtypes based on WHO histological classification criterion (classic vs variant medulloblastoma) and molecular subtypes classification criterion (WNT subgroup vs SHH subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).[1][2][3][4][5]
Classification
WHO histological classification criteria
- Medulloblastoma may be classified into two subtypes based on WHO histological classification criteria which include classic medulloblastoma and variant medulloblastoma.
- Other variants of medulloblastoma include desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity.[4][5][2]
WHO histological classification criteria | |||||||||||||||||||||||||||||||||||||||
Classic medulloblastoma | Variant medulloblastoma | ||||||||||||||||||||||||||||||||||||||
Desmoplastic medulloblastoma | Large cell medulloblastoma | Anaplastic medulloblastoma | Medulloblastoma with extensive nodularity | ||||||||||||||||||||||||||||||||||||
Molecular classification criteria
- Medulloblastoma may be classified into at least four major subtypes based on molecular classification criteria which include WNT subgroup, SHH subgroup, Group C and Group D medulloblastoma.[1][3]
Genomic classification criteria | |||||||||||||||||||||||||||||||||||||||
WNT subgroup | Sonic hedgehog (SHH) subgroup | Group 3 medulloblastoma | Group 4 medulloblastoma | ||||||||||||||||||||||||||||||||||||
References
- ↑ 1.0 1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
- ↑ 2.0 2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
- ↑ 3.0 3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
- ↑ 4.0 4.1 Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015
- ↑ 5.0 5.1 Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015