B-cell prolymphocytic leukemia

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B-cell prolymphocytic leukemia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]

Synonyms and keywords: B-PLL

Overview

Historical Perspective

Classification

Pathophysiology

Differentiating B-cell prolymphocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Overview

B-cell prolymphocytic leukemia is a more aggressive but still treatable form of leukemia. The malignant B cells are larger than average.


Diagnosis exam

  • Blood chemistry studies
  • Bone marrow aspiration and biopsy
  • Complete blood count (CBC)
  • CT (CAT) scan
  • Cytogenetic analysis
  • Immunophenotyping
  • Peripheral blood smear
  • Physical exam and history (H&P)

Stem cell trasplant

A stem cell transplant is sometimes used to treat people with aggressive prolymphocytic leukemia. Many people with prolymphocytic leukemia are older or may not be in good health, so a stem cell trasplant is often not a suitable option for them. However, it may be an effective option for younger people with prolymphocytic leukemia.

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