Optic nerve glioma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Optic nerve glioma was first described in 1816 by Scarpa.

Historical Perspective

Optic pathway gliomas are glial tumors that can affect the optic nerves, chiasm, tracts, and radiations, as well as adjacent neurologic structures. Since Scarpa first described an optic nerve glioma in 1816,1 many case reports and reviews have followed in order to characterize these lesions further. There is considerable controversy in the literature over the biologic behavior and optimum therapy for these tumors. Recent large literature reviews have proved to be valuable resources when considering management of patients with optic glioma. The reader is directed to excellent reviews conducted by Alvord and Lofton2 in 1988, and most recently by Dutton3 in 1994. After discussing the clinical features and diagnostic appearance of optic pathway gliomas, this chapter will provide an overview of various treatment regimens. Attention will then be directed to a different entity, the rare malignant optic glioma of adulthood, which is both aggressive and lethal.

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