Oligodendroglioma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for oligodendroglioma include biopsy and fluorescent in-situ hybridization (FISH) technique.

On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus, giving them a “fried egg” appearance.
Biopsy may be done at the time of surgical resection of oligodendroglioma.
Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
Biopsy may be of two types: open and stereotactic.
Indications for open biopsy and stereotactic biopsy are described below:^[1]


Type of biopsy	Indications

Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse lesions; multiple lesions; an appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)