Sandbox: WHO leukemia classification

Mature B-cell neoplasms

    Chronic lymphocytic leukemia/small lymphocytic lymphoma

    B-cell prolymphocytic leukemia

    Splenic marginal zone lymphoma

    Hairy cell leukemia

    Splenic lymphoma/leukemia, unclassifiable*

        Splenic diffuse red pulp small B-cell lymphoma*

        Hairy cell leukemia variant*

    Lymphoplasmacytic lymphoma

        Waldenström macroglobulinemia

    Heavy chain diseases

        α Heavy chain disease

        γ Heavy chain disease

        μ Heavy chain disease

    Plasma cell myeloma

    Solitary plasmacytoma of bone

    Extraosseous plasmacytoma

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

    Nodal marginal zone lymphoma

        Pediatric nodal marginal zone lymphoma*

    Follicular lymphoma

        Pediatric follicular lymphoma*

    Primary cutaneous follicle centre lymphoma

    Mantle cell lymphoma

    Diffuse large B-cell lymphoma (DLBCL), NOS

        T-cell/histiocyte rich large B-cell lymphoma

        Primary DLBCL of the CNS

        Primary cutaneous DLBCL, leg type

        EBV-positive DLBCL of the elderly*

    DLBCL associated with chronic inflammation

    Lymphomatoid granulomatosis

    Primary mediastinal (thymic) large B-cell lymphoma

    Intravascular large B-cell lymphoma

    ALK-positive large B-cell lymphoma

    Plasmablastic lymphoma

    Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease

    Primary effusion lymphoma

    Burkitt lymphoma

    B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma

     B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

Mature T-cell and NK-cell neoplasms

    T-cell prolymphocytic leukemia

    T-cell large granular lymphocytic leukemia

    Chronic lymphoproliferative disorder of NK cells*

    Aggressive NK-cell leukemia

    Systemic EBV-positive T-cell lymphoproliferative disease of childhood

    Hydroa vacciniforme-like lymphoma

    Adult T-cell leukemia/lymphoma

    Extranodal NK/T-cell lymphoma, nasal type

    Enteropathy-associated T-cell lymphoma

    Hepatosplenic T-cell lymphoma

    Subcutaneous panniculitis-like T-cell lymphoma

    Mycosis fungoides

    Sézary syndrome

    Primary cutaneous CD30+ T-cell lymphoproliferative disorders

        Lymphomatoid papulosis

        Primary cutaneous anaplastic large cell lymphoma

    Primary cutaneous γδ T-cell lymphoma

    Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma*

    Primary cutaneous CD4+ small/medium T-cell lymphoma*

    Peripheral T-cell lymphoma, NOS

    Angioimmunoblastic T-cell lymphoma

    Anaplastic large cell lymphoma, ALK-positive

    Anaplastic large cell lymphoma, ALK-negative*

Hodgkin lymphoma

    Nodular lymphocyte predominant Hodgkin lymphoma

    Classical Hodgkin lymphoma

    Nodular sclerosis classical Hodgkin lymphoma

    Lymphocyte-rich classical Hodgkin lymphoma

    Mixed cellularity classical Hodgkin lymphoma

    Lymphocyte-depleted classical Hodgkin lymphoma

Histiocytic and dendritic cell neoplasms

    Histiocytic sarcoma

    Langerhans cell histiocytosis

    Langerhans cell sarcoma

    Interdigitating dendritic cell sarcoma

    Follicular dendritic cell sarcoma

    Fibroblastic reticular cell tumor

    Intermediate dendritic cell tumor

    Disseminated juvenile xanthogranuloma

Posttransplantation lymphoproliferative disorders (PTLDs)

    Early lesions

        Plasmacytic hyperplasia

        Infectious mononucleosis–like PTLD

    Polymorphic PTLD

    Monomorphic PTLD (B- and T/NK-cell types)†

    Classical Hodgkin lymphoma type PTLD†