Sandbox: DDx 2

Differential Diagnosis	Key Symptoms	Characteristic Lab Findings	Imaging	Histopathology
Insulinoma	Weight loss Vague abdominal pain Loss of appetite Nausea and vomiting Jaundice Anxiety Diaphoresis Tremor Palpitations Seizures Coma	Hypoglycemia Hyperinsulinemia Elevated C-peptide level Elevated Pro-insulin level	Solid or gyriform patterns, usually without glands
VIPoma	<1.5 cm² residual tumor after resection	Subtotal resection or >1.5 cm² residual tumor after resection	<1.5 cm² residual tumor after resection	Subtotal resection or >1.5 cm² residual tumor after resection
Tumor stage	M0 stage confirmed by MRI and CSF sampling	M1-M3 stage or presence of leptomeningeal seeding	M0 stage confirmed by MRI and CSF sampling	M1-M3 stage or presence of leptomeningeal seeding