Sandbox: HCL therapy

Initial patients evaluation

History Physical examination Complete blood count

Asymptomatic patients with no therapeutic indications

Symptomatic patients or evidence of therapeutic indications

Patients managed by observation and close follow-up

Manage with either cladribine or pentostatin

Fit patients (CIRS <6)

Frail patients (CIRS ≥6)

FISH chromosomal analysis

Obinutuzumab AND chlorambucil Ofatumumab AND chlorambucil Rituximab AND chlorambucil

Immunochemotherapeutic regimens for the management of patients without chromosome 17p deletion or chromosome 11q deletion can be found here

Immunochemotherapeutic regimens for the management of patients with chromosome 17p deletion can be found here

Immunochemotherapeutic regimens for the management of patients with chromosome 11q deletion can be found here

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