Sandbox:DDx HEENT
- 65 yo women
- Rapidly enlarging neck mass
- Neck pain, dyspnea, dysphagia, and hoarseness
- Constitutional symptoms
- Tender hard nodular goiter
- Extensive lymphadenopathy
- Pleomorphic giant cells
- Connective tissue septae
- Necrosis and vascular invasion
- Increased mitotic activity
- Rhabdoid inclusions
- Well-differentiated cells palisading at necrotic edges
- BRAF gene mutation
- p53 gene mutation