Mesoblastic nephroma pathophysiology

Mesoblastic nephroma Microchapters
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Differentiating Mesoblastic nephroma from other Diseases
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Gross Pathology

Characteristic findings of mesoblastic nephroma include:

• Solid un-encapsulated mass
• Often occurs near the renal hilum
• Tends to invade the surrounding structures and renal parenchyma
• Hemorrhage and necrosis are infrequent

Microscopic Pathology

Classic mesoblastic nephroma

• Spindle cells in fasciclesHumphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
• Infiltrative border

Cellular mesoblastic nephroma

• Plump cells with vesicular nuclei
• Well-defined border
• Mitotically active

Mixed mesoblastic nephroma

• Both classic pattern and cellular pattern areas are present

Genetics

t(12:15)(p13;q25) ETV6/NTRK3.