Sandbox: DDx Kidney mass
- 30 yo patients
- Abdominal, flank, or back pain
- Hematuria, hypertenstion, intracranial hemorrhage
- ESRD at age 60
- Progressive decrease in GFR
- Elevated creatinine and BUN
- Multiple bilateral renal cysts on U/S
- Anechoic with well-defined imperceptible walls
- Palpable, bilateral flank masses
- Nodular hepatomegaly
- Fluid filled saccular expansions of glomerular capsule and renal tubule
- Located in the cortex and medulla
- Lined by cuboidal epithelium
- Disconnection of the glomerular capsule
- Polyps and papillary projections
- Areas of tubular atrophy, interstitial fibrosis, and global sclerosis are present between cyst
- PKD1 gene at chromosome 16
- PKD2 gene at chromosome 4
Nonmalignant causes
acquired cystic kidney disease cystic renal dysplasia glomerulocystic kidney medullary sponge kidney mesothelial cysts nephronophthisis simple cysts