Waldenström's macroglobulinemia
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Waldenström's macroglobulinemia On the Web |
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American Roentgen Ray Society Images of Waldenström's macroglobulinemia |
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Directions to Hospitals Treating Waldenström's macroglobulinemia |
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Risk calculators and risk factors for Waldenström's macroglobulinemia |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Synonyms and keywords: Primary macroglobulinemia; B-cell lymphoproliferative disease; Lymphoplasmacytoid lymphoma, Lymphoplasmacytoid Lymphomas; Macroglobulinemia; Plasmacytoid lymphocytic lymphoma; Familial Waldenstrom's Macroglobulinaemia; Familial Waldenstrom Macroglobulinaemia
Overview
Historical Perspective
- Waldenström's macroglobulinemia was first discovered by Jan G. Waldenström, a Swedish physician in 1944 in two patients with bleeding from the nose and mouth, anemia, decreased levels of fibrinogen in the blood (hypofibrinogenemia), swollen lymph nodes, neoplastic plasma cells in bone marrow, and increased viscosity of the blood due to increased levels of a class of heavy proteins called macroglobulins.[1]
Pathophysiology
Causes
- The most common causes are a somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients).[1]
Differentiating Waldenström's macroglobulinemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Bone Marrow Aspiration and Biopsy | Electrophoresis and Immunofixation | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies