Sandbox: DDx Kidney mass

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60-70 male patients von Hippel-Lindau syndrome


Polygonal cells, clear cytoplasm, and a central nucleus Delicate branching vasculature "Chicken wire-like" vasculature Hyaline bodies common


Chromosome 3 mutation VHL gene mutation Gain of chromosome 5

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

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