Waldenström's macroglobulinemia differential diagnosis
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:[1]
- Chronic lymphocytic leukemia/small lymphocytic lymphoma:
- Always express CD5, usually CD23 positive
- B-cell prolymphocytic leukemia:
- Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)
- Follicular lymphoma:
- Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA
- Multiple myeloma:
- Express CD138, CD38, CD79a, and VS38c and CD56(70%)
- Mantle cell lymphoma:
- Express CD5+ and CD23-, surface IgM and IgD and cyclin D1 in majority of cases
- Marginal zone lymphoma:
- Expresses B cell markers CD19, CD20, and CD22
References=
- ↑ Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015