Sandbox: maria

Medulloblastoma Microchapters
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Overview
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Pathophysiology
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Differentiating Medulloblastoma from other Diseases
Epidemiology and Demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Pathogenesis

• Medulloblastoma arises from embryonal cells, which are stem cells that are normally involved in development of the fourth ventricle.

Genetics

• Development of medulloblastoma is the result of multiple genetic mutations.
• Genes involved in the pathogenesis of medulloblastoma include:

• CTNNB1
• PTCH1
• MLL2
• SMARCA4

• DDX3X
• CTDNEP
• KDM6A

• TBR1

References

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